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20

Compounds

Cat No. Product Name Synonyms Targets
T40117 Antileishmanial agent-1
Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM).
T79449 Antileishmanial agent-19 Parasite
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and d...
T78964 Antileishmanial agent-17 Parasite
Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine redu...
T79471 Antileishmanial agent-20 Parasite
Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L. infantum and 0.2 μM for L. braziliensis. It is a potential research tool for studying these parasites [1].
T60638 Antileishmanial agent-8
Antileishmanial agent-8 (compound 18) shows potent and selective activity against Leishmania donovani ( L. donovani ) (IC50 = 5.64 μM) with relatively low cytotoxicity in L-6 cells (IC 50 =73.9 μM) [1].
T79633 Antileishmanial agent-22 Parasite
Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and tuberculosis. It operates on an antifolate mechanism, suppres...
T61199 Antileishmanial agent-2
Antileishmanial agent-2 demonstrates potent submicromolar antileishmanial activity (IC50 = 0.29 μM) and a remarkable selectivity index against mammalian cells.
T61710 Antileishmanial agent-7
Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1].
T61391 Antileishmanial agent-3
Antileishmanial agent-3 (Compound 13) effectively inhibits the growth of Leishmania major [1].
T63281 Antileishmanial agent-11
Antileishmanial agent-11 is a potent antileishmanial agent that acts on Leishmania brazilensis (IC50: 28.3 μM), Leishmania infantum (IC50: 24.8 μM) and T. cruzi (IC50: 13.0 μM) with outstanding antiprotozoal effect.
T62574 Antileishmanial agent-6
Antileishmanial agent-6 is a potent anti-leishmanial agent with anti-leishmanial activity (IC50: 0.54 μM) and cytotoxicity (IC50: 10.2 μM) against Leishmania donovani and L-6.
T61560 Antileishmanial agent-5
Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1].
T78963 Antileishmanial agent-16 Parasite
Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety p...
T61100 Antileishmanial agent-4
Antileishmanial agent-4, a ribonucleoside analogue, functions as an antileishmanial agent [1].
T79419 Antileishmanial agent-24 Parasite
Antileishmanial agent-24 (compound 33) exhibits antileishmanial activity, demonstrating an inhibitory concentration 50 (IC50) value of 5.39 μM against amastigotes [1].
T62210 Antileishmanial agent-10
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent.
T72260 Antileishmanial agent-13
Antileishmanial agent-13, a quinoline-isatin hybrid, functions as an antileishmanial agent targeting the L. Major Leishmania strain through an anti-folate mechanism. This compound exhibits potent inhibition of both the p...
T83045 Antileishmanial agent-25 Parasite
Antileishmanial agent-25 (compound 24) exhibits selective activity against intracellular amastigotes, demonstrating an inhibitory concentration (IC50) of 6.63 μM [1].
T79632 Antileishmanial agent-21 Parasite
Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin....
T78680 Antileishmanial agent-14 Parasite
Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by L. donovani amastigotes (IC 50 = 11.1 μM) [1].
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