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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13888 | SLF | Others | |
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC. | |||
T18061 | KB02-SLF | Others | |
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of p... | |||
T13914 | SLF-amido-C2-COOH | PROTAC FKBP12-binding moiety 1 | Others |
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs. | |||
T73817 | SLF TFA | ||
SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1]... | |||
T61112 | SLF1081851 | LPL Receptor | |
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM. | |||
T62851 | SLF1081851 TFA | ||
SLF1081851 (TFA) is a Spns2 inhibitor with an IC50 value of 1.93 μM for inhibition of S1P release.SLF1081851 (TFA) plays a key role in development and the immune system. | |||
T74026 | AUTAC2 | ||
AUTAC2, an autophagy-mediated degrader (AUTAC) targeting FKBP12, comprises an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. The SLF component binds non-covalently to FKBP12 [1]. | |||
T18597 | DFKBP-1 | Others | |
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1]. | |||
T80928 | TSPO ligand-3 | AUTACs | |
TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1]. | |||
T39923 | KB02-COOH | KB02-COOH | |
KB02-COOH is a synthetic fragment derived from ubiquitin E3 ligase ligand KB02, which possesses potential utility in the synthesis of PROTAC compounds. Notably, KB02-COOH can be employed in the generation of PROTAC const... |