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Search Results for " sik2-in-1 "

4

Compounds

Cat No. Product Name Synonyms Targets
T78196 SIK2-IN-1
SIK2-IN-1 (compound 8g) is a potent inhibitor of SIK2 with selectivity over other AMPK-family kinases, demonstrating favorable ADMET profiles in vitro and robust cellular activities [1].
T0097 MRT67307 MRT67307 HCl IκB/IKK , Autophagy
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...
T74644 DB0614
DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK...
T23028 MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl Others
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i...
TargetMol