rev-erb — TargetMol Chemicals

Search Result

Search Results for " rev-erb "

Compounds

Cat No.	Product Name	Synonyms	Targets
T3685	SR9009	Stenabolic,REV-ERB Agonist II	Autophagy
	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during...		Autophagy
T12998	SR10067		Others , Autophagy
	SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbα/β(IC50 of 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively),has anxiolytic activity.		Others , Autophagy
T7837	SR8278		Others
	SR8278 is an REV-ERBα antagonist(EC50 = 0.47 µM), blocking activation of the receptor by the synthetic agonist GSK 4112		Others
T3688	SR9011		Autophagy
	SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).		Autophagy
T61883	ARN5187
	ARN5187 is a lysosomal compound, REV-ERB β Ligand. ARN5187 inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomal efficacy and cytotoxicity, and can induce apoptosis.
T63206	SR12418
	SR12418 is a specific REV-ERB synthetic ligand that acts on REV-ERBα (IC50: 68 nM) and REV-ERBβ (IC50: 119 nM) and can be used to study experimental autoimmune encephalomyelitis (EAE) and colitis.
T63476	ARN5187 trihydrochloride
	ARN5187 trihydrochloride is a lysosomal REV-ERBβ ligand that inhibits REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride has lysosomal potency and cytotoxicity and induces apoptosis.
T73443	STL1267
	STL1267, a potent REV-ERB agonist capable of crossing the blood-brain barrier, exhibits a K i value of 0.16 µM for REV-ERBα without demonstrating cytotoxicity. It effectively inhibits the gene expression of BMAL1.