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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T73585 | PU.1-IN-1 | ||
PU.1-IN-1 is a potent PU.1 inhibitor (IC50 : 2 nM) with anti-inflammatory activity. | |||
T10964 | DB1976 | Apoptosis , Others | |
DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA comp... | |||
T69842 | DB2313 HCl | ||
DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets. | |||
T38778 | DB2115 tertahydrochloride | DB2115 tertahydrochloride | |
DB2115 (tertahydrochloride) is a powerful inhibitor of the myeloid master regulator PU.1. With significant potential in cancer research, particularly hematologic cancers like leukemia, as well as other conditions linked ... | |||
T10964L | DB1976 dihydrochloride | DB1976 hydrochloride,DB1976 2HCl | Apoptosis , NF-κB |
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and improved glucose homeostasis and dyslipidemia in mice in i... | |||
T78201 | PU-48 | ||
PU-48 is a potent inhibitor of urea transporters A (UT-A) with an IC50 value of 0.32 μM, exhibiting a significant diuretic effect in mouse models without notable cytotoxicity. This compound has the potential for further ... | |||
T14293 | Annonacin | Others | |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarco... | |||
T38021 | Obafluorin | ||
Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). |1. Pu, Y., Lowe, C., Sailer, M., et al.... |