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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP1071 | Nociceptin | Orphanin FQ | Opioid Receptor |
Nociceptin (Orphanin FQ) is a 17-amino-acid polypeptide that is structurally related to the opioid peptide dynorphin A. | |||
T23076L | Nociceptin (1-7) acetate | Opioid Receptor | |
Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity. | |||
TP1793L | Nociceptin (1-13) amide TFA | Opioid Receptor | |
Nociceptin (1-13), amide is a potent agonist Opioid receptor-like1 (ORL1) receptor with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes. | |||
TP1885L1 | [(pF)Phe4]Nociceptin(1-13)NH2 acetate | Opioid Receptor | |
[(pF)Phe4]Nociceptin(1-13)NH2 acetate is a selective agonist of NOP receptor with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 acetate displays high selectivity over δ, κ, and μ opioid receptors (>30... | |||
T23076 | Nociceptin(1-7) | Nociceptin (1-7) | Others |
Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesia | |||
TP1986 | [Arg14,Lys15]Nociceptin | ||
Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasti... | |||
TP1793 | Nociceptin (1-13), amide | Opioid Receptor | |
Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes. | |||
TP1987 | [Nphe1]Nociceptin(1-13)NH2 | ||
Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitr... | |||
TP1885 | [(pF)Phe4]Nociceptin(1-13)NH2 | ||
Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronocicep... | |||
TP1988 | [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 | ||
Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum a... | |||
T75906 | Nociceptin (1-13), amide TFA | ||
Nociceptin (1-13), amide TFA, a potent ORL1 receptor (opioid receptor-like 1 receptor, OP4) agonist, exhibits a pEC 50 of 7.9 in mouse vas deferens and a K i of 0.75 nM for rat forebrain membrane binding [1] [2]. | |||
T75908 | Nociceptin(1-7) TFA | ||
Nociceptin (1-7) TFA, the N-terminal bioactive fragment of nociceptin, serves as a potent ORL 1 (NOP) receptor agonist, exhibiting antinociceptive properties. Its combination with nociceptin effectively reduces hyperalge... | |||
T75896 | [Arg14,Lys15]Nociceptin TFA | ||
[Arg14,Lys15]Nociceptin TFA is a potent and selective agonist for the NOP receptor (ORL1; OP4), exhibiting an EC50 of 1 nM. It demonstrates significant selectivity against opioid receptors, with IC50 values of 0.32 nM fo... | |||
T75909 | [Nphe1]Nociceptin(1-13)NH2 TFA | ||
[Nphe1]Nociceptin(1-13)NH2 is a novel endogenous ligand for the nociceptin/orphanin FQ (NC) receptor, acting as a selective and competitive antagonist without any agonist effects. It binds specifically to recombinant noc... | |||
T28728 | SCH-486757 | ||
SCH-486757, a nociceptin receptor (NOP) agonist, is used potentially for the treatment of cough. | |||
T2071 | MCOPPB triHydrochloride | MCOPPB trihydrochlride,MCOPPB 3HCl | Opioid Receptor |
MCOPPB triHydrochloride (MCOPPB 3HCl) is a nociceptin receptor agonist. | |||
TP1940L1 | Ac-RYYRIK-NH2 acetate | Opioid Receptor | |
Ac-RYYRIK-NH2 acetate is an agonist at nociceptin/orphanin FQ(noc/OFQ) receptors, affecting spontaneous locomotor activity. Ac-RYYRIK-NH2 acetate is a partial agonist on ORL1 transfected in CHO cells, antagonizes the sti... | |||
TP1941L1 | Ac-RYYRWK-NH2 acetate | Opioid Receptor | |
Ac-RYYRWK-NH2 acetate is a potent partial agonist of the nociceptin receptor(NOP), which is the endogenous ORL1 receptor agonist. | |||
TP1882L1 | Orphanin FQ(1-11) acetate(178249-41-7 free base) | Opioid Receptor | |
Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays a... | |||
T15799 | LY2940094 | LY-2940094 | Opioid Receptor |
LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist pot... |