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[Arg14,Lys15]Nociceptin

Catalog No. TP1986 CAS 236098-40-1

Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays < 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, < 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

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[Arg14,Lys15]Nociceptin Chemical Structure

[Arg14,Lys15]Nociceptin, CAS 236098-40-1

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1 mg	Inquiry	$ 198.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

Molecular Weight	1909.18
Formula	C82H137N31O22
CAS No.	236098-40-1

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1 mg/mL

References and Literature

1. Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID: 2. Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493 PMID: 3. Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57 PMID:

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

[Arg14,Lys15]Nociceptin 236098-40-1 [Arg-14,Lys15]Nociceptin inhibitor inhibit

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