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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6880 | Larotrectinib sulfate | LOXO-101 sulfate,Larotrectinib (LOXO-101) sulfate,Larotrectinib,LOXO-101 (sulfate),ARRY-470,ARRY-470 (sulfate) | Apoptosis , Trk receptor |
Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). | |||
T5995 | Larotrectinib | LOXO-101,ARRY-470 | Apoptosis , Trk receptor |
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM). | |||
T62531 | TRK-IN-12 | ||
TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM). It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (I... |