hpk1-in-2 — TargetMol Chemicals

Search Result

Search Results for " hpk1-in-2 "

Compounds

Cat No.	Product Name	Synonyms	Targets
T9017	HPK1-IN-2	Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2,HPK1-IN-2	Others , FLT , Src
	HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also...		Others , FLT , Src
T72036	HPK1-IN-36		Others
	HPK1-IN-36 (compound 2) is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1), demonstrating an inhibitory concentration 50 (IC50) of 0.5 nM [1].		Others
T63287	HPK1-IN-3
	HPK1-IN-3 is a selective, potent, ATP-competitive inhibitor of hematopoietic progenitor cell kinase 1 (HPK1; MAP4K1) (IC50: 0.25 nM). HPK1-IN-3 has IL-2 cellular potency and is able to act on human peripheral blood monon...
T73149	HPK1-IN-33
	HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cel...
T78688	HPK1-IN-35
	HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1].