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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T60532 | HIF-1α-IN-5 | ||
HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has... | |||
T74530 | GEM-5 | ||
GEM-5, a gemcitabine-based conjugate incorporating a HIF-1α inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF-1α expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and c... | |||
T69966 | Roxadustat-d5 | ||
Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.... | |||
T36404 | PRLX-93936 | ||
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1... | |||
T36749 | Herboxidiene | ||
Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin... |