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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T63432 | HER2-IN-5 | ||
HER2-IN-5 is an effective inhibitor of orally active HER-2. | |||
T64254 | EGFR/HER2-IN-5 | ||
EGFR/HER2-IN-5 is an irreversible, orally active dual inhibitor of EGFR activity (IC50: 0.6 nM). EGFR/HER2-IN-4 shows potent EGFR kinase inhibitory activity against L858R and T790M mutations. EGFR/HER2-IN-4 exhibits sign... | |||
T36242 | PROTAC BRD4 Degrader-5 | PROTAC BRD4 Degrader-5 | |
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. | |||
T82485 | ELAAWCRWGFLLALLPPGIAG | ||
ELAAWCRWGFLLALLPPGIAG (P5), a 21-amino acid peptide (aa 5-25) derivative of the rat HER2/neu protein, has been shown to elicit cytotoxic T lymphocyte (CTL) responses in mice with HER2-positive tumors [1]. | |||
T82484 | ELAAWCRWGFLLALLPPGIAG TFA | ||
ELAAWCRWGFLLALLPPGIAG TFA (P5), a 21-amino-acid peptide (aa 5-25) originating from the rat HER2/neu protein, has been shown to elicit cytotoxic T lymphocyte (CTL) responses in mice with HER2-positive tumors [1]. | |||
T80590 | Cinrebafusp alfa | PRS 343 | EGFR |
Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM to recombinant human HER2 and 5 nM to human monomeric CD137 (4-1BB... | |||
T37329 | PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 | |
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the... |