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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11421 | Glutaminase-IN-1 | CB839 derivative | transporter |
Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine renal-type glutaminase (KGA) variant inhibitor, showed antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model. | |||
T3964 | Glutaminase C-IN-1 | Compound 968,Glutaminase Inhibitor Compound 968 | Glutaminase |
Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor. | |||
T37385 | Glutaminase-IN-3 | Glutaminase | |
Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research. | |||
T39309 | Telaglenastat hydrochloride | CB-839 hydrochloride | |
Telaglenastat (CB-839) hydrochloride is a first-in-class, reversible, and orally active inhibitor of glutaminase 1 (GLS1). It selectively inhibits the splice variants of GLS1, specifically KGA (kidney-type glutaminase) a... | |||
T83914 | Glutaminase C Inhibitor 11 | ||
Glutaminase C Inhibitor 11 is a potent inhibitor specifically targeting Glutaminase C (GAC), demonstrating significant inhibition of GAC enzyme activity with an EC50 value of 10.64 nM. It effectively diminishes the viabi... | |||
T78892 | Glutaminase C-IN-2 | Glutaminase | |
Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM. By disrupting glutamine metabolism, this compound modulates cellular metabol... | |||
T37222 | GLS1 Inhibitor | ||
GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50= 0.021 μM).1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI50= 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growt... | |||
T39544 | IPN60090 dihydrochloride | IPN60090 dihydrochloride | |
IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-6009... | |||
T73458 | LWG-301 | ||
LWG-301, an allosteric inhibitor of Glutaminase 1 (GLS1), demonstrates a potent inhibition with an IC50 value of 7 nM. It effectively impedes glutamine metabolism and elevates intracellular ROS levels, thereby inducing a... |