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Search Results for " glun2a "

15

Compounds

Cat No. Product Name Synonyms Targets
T7870 TCN 201 TCN-201 NMDAR , iGluR
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T16801 (RS)-(Tetrazol-5-yl)glycine LY 285265,D,L-(tetrazol-5-yl)glycine NMDAR , iGluR
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1...
T8450 TCN 213 TCN213 NMDAR
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
T22748 DQP 1105 NMDAR
DQP 1105 is a NMDA receptor antagonist.
T15407 GNE-0723 Others
GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively).
T31980 GNE-6901 GNE6901,GNE 6901
GNE-6901 is a selective GluN2A PAM.
T15408 GNE 5729 Others
GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively).
T31979 GNE-3476 GNE 3476
GNE-3476 is an NMDA receptor PAM. Ge-3476 has different degrees of activity on different receptors.GNE-3476 has relatively low efficacy on GluN2A, some activity as an AMPAR PAM, and weak activity at GluN2B-containing rec...
T73491 TP-050
TP-050 is a potent, selective NMDAR agonist that is orally active, showing EC50 values of 0.51 µM for GluN2A and 9.6 µM for GluN2D. This compound can cross the blood-brain barrier (BBB), enhancing hippocampal long-term (...
T28093 MPX-007 MPX 007
MPX-007, a potent NMDA inhibitor, inhibits GluN2A-containing NMDA receptors expressed in HEK cells with IC50s of 27 nM.
T19881 UBP608 UBP-608,UBP 608
UBP608 is an allosteric modulator of NMDA receptor family. It selectively inhibits GluN1/GluN2A receptors with a 23-fold selectivity compared to GluN1/GluN2D receptors.
T69906 PEAQX sodium
PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the K...
T61227 NAB-14
NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compou...
TP2060 Conantokin G
GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (forma...
T73359 NYX-2925
NYX-2925, an orally active NMDAR (N-methyl-D-aspartate receptor) modulator, enhances activated Src levels and Src phosphorylation at GluN2A and GluN2B sites in the mPFC (medial prefrontal cortex), without affecting CAMKI...
TargetMol