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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7870 | TCN 201 | TCN-201 | NMDAR , iGluR |
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit. | |||
T16801 | (RS)-(Tetrazol-5-yl)glycine | LY 285265,D,L-(tetrazol-5-yl)glycine | NMDAR , iGluR |
(RS)-(Tetrazol-5-yl)glycine (LY 285265) (D,L-(tetrazol-5-yl)glycine) is an effective and selective N-methyl-D-aspartate receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D, and GluN1... | |||
T8450 | TCN 213 | TCN213 | NMDAR |
TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B | |||
T22748 | DQP 1105 | NMDAR | |
DQP 1105 is a NMDA receptor antagonist. | |||
T15407 | GNE-0723 | Others | |
GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively). | |||
T31980 | GNE-6901 | GNE6901,GNE 6901 | |
GNE-6901 is a selective GluN2A PAM. | |||
T15408 | GNE 5729 | Others | |
GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively). | |||
T31979 | GNE-3476 | GNE 3476 | |
GNE-3476 is an NMDA receptor PAM. Ge-3476 has different degrees of activity on different receptors.GNE-3476 has relatively low efficacy on GluN2A, some activity as an AMPAR PAM, and weak activity at GluN2B-containing rec... | |||
T73491 | TP-050 | ||
TP-050 is a potent, selective NMDAR agonist that is orally active, showing EC50 values of 0.51 µM for GluN2A and 9.6 µM for GluN2D. This compound can cross the blood-brain barrier (BBB), enhancing hippocampal long-term (... | |||
T28093 | MPX-007 | MPX 007 | |
MPX-007, a potent NMDA inhibitor, inhibits GluN2A-containing NMDA receptors expressed in HEK cells with IC50s of 27 nM. | |||
T19881 | UBP608 | UBP-608,UBP 608 | |
UBP608 is an allosteric modulator of NMDA receptor family. It selectively inhibits GluN1/GluN2A receptors with a 23-fold selectivity compared to GluN1/GluN2D receptors. | |||
T69906 | PEAQX sodium | ||
PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the K... | |||
T61227 | NAB-14 | ||
NAB-14 is a powerful and selective chemical compound that acts as a non-competitive antagonist for GluN2C and GluN2D receptors. With an IC50 value of 580 nM for GluN1/GluN2D, NAB-14 demonstrates high potency. This compou... | |||
TP2060 | Conantokin G | ||
GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (forma... | |||
T73359 | NYX-2925 | ||
NYX-2925, an orally active NMDAR (N-methyl-D-aspartate receptor) modulator, enhances activated Src levels and Src phosphorylation at GluN2A and GluN2B sites in the mPFC (medial prefrontal cortex), without affecting CAMKI... |