4
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11441 | GNE-987 | Epigenetic Reader Domain | |
GNE-987 is a highly active chimeric BET degrader. GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50: 4.7 and 4.4 nM, respectively). GNE-987 exhibits picomolar cell BRD... | |||
T12798 | (S)-GNE-987 | Epigenetic Reader Domain | |
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC). | |||
T12551 | PROTAC BRD4 ligand-1 | Epigenetic Reader Domain , Ligands for Target Protein for PROTAC | |
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET. | |||
T18603 | PROTAC BRD4 degrader for PAC-1 | Others | |
PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective pro... |