g551d — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T7083	GLPG1837	ABBV-974	CFTR , Autophagy
	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.		CFTR , Autophagy
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy
T16516	PG01	Phenylglycine-01	CFTR
	PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508...		CFTR
T40386	CP-628006
	CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.