fak — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T77718	FAK-IN-10		FAK
	FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.		FAK
T9973	FAK-IN-7		FAK
	FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.		FAK
T7119	Y15	1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14	FAK
	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.		FAK
T40183	FAK-IN-1
	FAK-IN-1 is a FAK inhibitor with anticancer activities (WO2020231726 (Example 27)).
T11260	FAK inhibitor 2		FAK
	FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .		FAK
T11261	FAK inhibitor 5		Others
	FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.		Others
T13840	PROTAC FAK degrader 1		Others
	PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).		Others
T17943	FAK ligand-Linker Conjugate 1		Others
	FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a r...		Others
T63545	FAK-IN-3
	FAK-IN-3 is a potent inhibitor of adherens spot kinase (FAK). FAK-IN-3 reduces migration and invasion of PA-1 cells and inhibits the expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis with no si...
T79688	FAK-IN-11		FAK
	FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation. It exhibits cytotoxic effects on MDA-MB-231 cells, achieving an IC50 value of 13.73 μM, and ind...		FAK
T61019	FAK-IN-4
	FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1].
T64077	FAK-IN-5
	FAK-IN-5 is a FAK signaling inhibitor that induces apoptosis and autophagy.
T64207	FAK-IN-6
	FAK-IN-6 is a potent inhibitor of FAK (IC50: 1.415 nM). FAK-IN-6 exhibits anti-proliferative effects on certain cancer cell lines and can be used to study pancreatic cancer.
T74802	FAK-IN-9
	FAK-IN-9 (Compound 8f) is a potent, orally active inhibitor of FAK, demonstrating an IC50 value of 27.44 nM. This compound effectively induces apoptosis in triple-negative breast cancer (TNBC) cells [1].
T63978	FAK-IN-2
	FAK-IN-2 is a potent, orally active adherens spot kinase (FAK) inhibitor (IC50: 35 nM) that exhibits antitumour effects. FAK-IN-2 covalently inhibits FAK autophosphorylation in a dose-dependent manner and also inhibits t...
T61410	FAK-IN-8
	FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].
T74281	FAK PROTAC B5
	Compound B5 (FAK PROTAC B5) is a FAK PROTAC degrader exhibiting potent FAK degradation and antiproliferative activities, with an IC50 of 14.9 nM. It also shows excellent plasma stability, moderate membrane permeability, ...
T82420	FAK-IN-12		FAK
	FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM. It effectively suppresses proliferation of MGC-803, HCT-116, and KYSE30 cells with IC50 values of 0.24, 0.45, and 0.44 μM, respectively. Additi...		FAK
T63123	FAK inhibitor 6
	Compound 26F effectively optimizes enzyme inhibition (IC50 = 28.2 nM) while demonstrating relatively low cytotoxicity (IC50 = 3.32 μM). It induces apoptosis in MDA-MB-231 cells in a dose-dependent manner and efficiently ...
T9576	AMP-945		FAK
	AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.		FAK