dgkα — TargetMol Chemicals

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Search Results for " dgkα "

Compounds

Cat No.	Product Name	Synonyms	Targets
T79823	DGKα-IN-4
	DGKα-IN-4 (example 432), an inhibitor of DGKα with an IC50 value of 0.1 nM. This compound notably potentiates the anti-tumor efficacy of anti-PD-1 therapy through augmentation of T cell proliferation and function. Additi...
T79826	DGKα-IN-6
	DGKα-IN-6, a diacylglycerol kinase alpha (DGKα) inhibitor characterized by an inhibitory concentration (IC50) of 1.377 nM,holds promise for use in cancer research.
T79828	DGKα-IN-8
	DGKα-IN-8 (Example 51) is a potent diacylglycerol kinase alpha (DGKα) inhibitor, exhibiting an IC50 of 22.491 nM and an EC50 of 0.256 nM. It is applicable in the research of cancer, particularly solid tumors, and viral i...
T79827	DGKα-IN-7
	DGKα-IN-7 is a potent DGKα inhibitor with an IC50 value of 6.225 nM and potential applications in cancer research.
T79822	DGKα-IN-3
	DGKα-IN-3 (example 25), with an IC50 of 283 nM, is a selective DGKα inhibitor that augments anti-PD-1's anti-tumor activity by promoting T cell proliferation and function, showing promise for cancer and immunology resear...
T79821	DGKα-IN-2
	DGKα-IN-2 (example 48), a potent DGKα inhibitor with an IC50 of 0.9 nM, exhibits potential for cancer and immunological research by significantly augmenting the anti-tumor efficacy of anti-PD-1 therapy through the amplif...
T79824	DGKα&ζ-IN-1
	DGKα&ζ-IN-1 (Compound II) is an inhibitor targeting DGK that potentiates T-cell function and exhibits a synergistic interaction with PD-1, offering therapeutic benefits in immune and tumor contexts [1].
T77760	BMS-684		Others
	BMS-684 is a selective and potent DGKα inhibitor (IC50: 15 nM) with potential antitumor activity.BMS-684 inhibits DGKα kinase, DGKβ, and DGKγ.BMS-684 activates T-cells, which may prevent and treat immune-related diseases...		Others
T26019	R59949	R-59949,R 59949	Others , PKC
	R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.		Others , PKC
T10177	(5Z,2E)-CU-3		Apoptosis
	(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 is selective, targeting the catalytic region ...		Apoptosis
T82850	BMS-332
	BMS-332 is a dual inhibitor of the lipid kinases DGKα and DGKζ, demonstrating half-maximal inhibitory concentrations (IC50) of 0.005 μM for DGKα and 0.001 μM for DGKζ [1].
T82849	BMS-496
	BMS-496 is a dual DGKα/ζ lipid kinase inhibitor exhibiting IC50 values of 0.09 μM (DGKα) and 0.006 μM (DGKζ) [1].
T63207	JNJ-3790339
	JNJ-3790339 is an analogue of Ritanserin, a selective and potent diacylglycerol kinase (DGKα) inhibitor (IC50: 9.6 μM) that upregulates T-cell activation and induces toxic effects on malignant cells.
T79819	AMB639752
	AMB639752 is a potent inhibitor of diacylglycerol kinase alpha (DGKα) that reinstates restimulation-induced cell death (RICD) in SAP-deficient lymphocytes through DGKα inhibition within intact cells. This compound is app...