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Search Results for " dd2 "

Targets

9

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10903 CWHM-1552 Parasite
CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.
T10902 CWHM-1008 Others
CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively.
T12084 MMV008138 Others
MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM).
T60302 4,4'-Dicyanostilbene
4,4'-Dicyanostilbene (compound 43) demonstrates potent antimalarial activity against the Dd2 strain, exhibiting an EC50 value of 27 nM, and exhibits in vivo efficacy against methicillin-resistant Staphylococcus aureus (M...
T35740 FR900098 (sodium salt)
FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the...
T63456 Antimalarial agent 12
Antimalarial agent 12 is an effective antimalarial agent that inhibits the growth of Plasmodium falciparum strains Dd2 and 3D7 with EC50 values of 155 nM and 136 nM, respectively. antimalarial agent 12 has a MIC >250,000...
T62300 Antimalarial agent 11
Antimalarial agent 11 (compound 1) is a potent antimalarial agent, a spirocyclic chromane. Antimalarial agent 11 is able to act on D6 (EC50: 1.48 μM) and ARC08-022 (EC50: 1.81 μM).
T36649 AN3661
AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains...
T38269 Purfalcamine
Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes mala...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03497 AKR1C2 Protein, Human, Recombinant (His) Human E. coli
AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using ...
TMPJ-00207 AKR1C2 Protein, Human, Recombinant Human E. coli
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation o...
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