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Search Results for " cholangitis "

9

Compounds

Cat No. Product Name Synonyms Targets
T3978 Linerixibat GSK2330672,Iinerixibat HBV
Linerixibat (GSK2330672) is a highly effective, nonabsorbable ASBT inhibitor (IC50: 42 ± 3 nM). It can lower glucose in an animal model of type 2 diabetes and shows excellent developability properties.
T31964 Glycolithocholic acid Lithocholic acid glycine conjugate,Lithocholylglycine Others
Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.
T64334 Glycolithocholic acid, sodium salt Others
Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s...
T10087 24-Norursodeoxycholic acid nor-UDCA Others
24-Norursodeoxycholic acid (nor-UDCA) is a side chain-shortened C23 homolog of UDCA.It has shown potent anti-inflammatory, anti-cholestatic, and anti-fibrotic properties.It is a Ursodeoxycholic Acid derivative. It is sup...
T76700 Simtuzumab GS 6624,AB 0024 Monoamine Oxidase
Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...
T69517 Bexotegrast HCl
Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activati...
T6582L Mezlocillin Bay-f 1353,Meslocillin,Melocin,Baypen,Mezlin
Meloxicillin is a broad-spectrum penicillin antibiotic that is active against both Gram-negative bacteria and some Gram-positive bacteria. Unlike most other broad-spectrum penicillin, it is excreted by the liver and can ...
T73414 EDP-305
EDP-305, an orally active, potent, and selective agonist of the farnesoid X receptor (FXR), exhibits EC50 values of 34 nM in chimeric FXR within CHO cells and 8 nM in full-length FXR in HEK cells. Demonstrating a potent ...
T73155 BMS-986339
BMS-986339 is an orally active, potent FXR agonist that interacts via H-bond formation with the His298 and ASN287 residues. It is utilized in research focused on primary biliary cirrhosis (PBC), primary sclerosing cholan...
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