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Search Result

Search Results for " caxii "

11

Compounds

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T60930 CAXII-IN-1
CAXII-IN-1 (Compound 17) has antitumor activity that is a selective inhibitor of CA XII. The Ki values of CAXII-IN-1 for hCA XII and hCA IX is 3.8 nM and 56.0 nM, respectively [1].
T2017 U-104 NSC-213841,MST-104 Carbonic Anhydrase
U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).
T61769 HCAXII-IN-5
hCAXII-IN-5 (compound 6o) is a highly effective and specific inhibitor of hCAXII. The compound exhibits impressive binding affinities, with Ki values of >10000, >10000, 286.1, and 1.0 nM for hCAI, hCAII, hCAIX, and hCAXI...
T63973 HCAXII-IN-3
hCAXII-IN-3 (Compound 6o) is a selective inhibitor of human carbonic anhydrase XII (hCAXII) (Ki: 10.0 nM).
T61219 HCAXII-IN-1
hCAXII-IN-1 demonstrates selective inhibition of tumor-related subtypes HCA IX and XII, making it potential leading molecules in the development of novel cancer therapeutic drugs with new mechanisms of action.
T79411 HCAXII-IN-7 Carbonic Anhydrase
hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability. Moreover, it promotes apoptosis in 786-0, SF-539, and HS 578 T cell line...
T62101 HCAXII-IN-2
hCAXII-IN-2 (compound 5i) is a potent inhibitor of human carbonic anhydrase XII (hCA XII) (Ki: 84.2 nM) and hCA IX (Ki: 268.5 nM), with low activity against hCA I and hCA II.
T63276 HCAXII-IN-4
hCAXII-IN-4 is a selective and potent CA XII inhibitor with a Ki value of 6.4 nM for human CA XII.
T61873 HCAIX/XII-IN-1
hCAIX/XII-IN-1, a potent inhibitor of both CAIX and CAXII, exhibits KI values of 0.48 μM for CAIX and 0.83 μM for CAXII, respectively. This compound demonstrates antiproliferative activity in vitro and induces apoptosis ...
T61384 HCAIX/XII-IN-4
hCAIX/XII-IN-4 (compound 6c) is a highly potent inhibitor of CAIX/XII. It exhibits Ki values of 4.5 nM, 23.6 nM, >10000 nM, and >10000 nM for CAXII, CAIX, CAI, and CAⅡ, respectively [1].
T36059 Dichlorphenamide-13C6 Dichlorphenamide-13C6
Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor ...

Recombinant Proteins

Species：
Human (2)
Cynomolgus (1)
Expression System：
HEK293 Cells (3)
Tag：
C-His (2)
His, Avi (1)
Cat No. Product Name Species Expression System
TMPY-00694 Carbonic Anhydrase 12 Protein, Human, Recombinant (His) Human HEK293 Cells
Carbonic Anhydrase 12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.6 kDa and the accession number is O43570-1.
TMPY-06944 Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Carbonic Anhydrase 12 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 33.45 kDa and the accession number is NP_001209.1...
TMPK-00478 Carbonic Anhydrase 12 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Carbonic anhydrases (CAs) are a family of enzymes involved in the pH regulation of metabolically active cells/tissues. Carbonic anhydrase XII (CA XII) is a key mediator of several signaling pathways that are involved in ...
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