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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T62578 | BuChE-IN-1 | ||
BuChE-IN-1 (Compound 23) is a potent, highly blood-brain barrier-permeable, low cytotoxicity inhibitor of butyrylcholinesterase (BuChE). BuChE-IN-1 is a BuChE inhibitor that has the potential to be used in the study of A... | |||
T72763 | AChE/BuChE-IN-1 | ||
AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) wi... | |||
T10630 | BuChE-IN-TM-10 | TM-10 | AChR |
BuChE-IN-TM-10 (TM-10) is a potent inhibitor of butyrylcholinesterase (BuChE), exhibiting an IC50 of 8.9 nM. It effectively inhibits and disaggregates self-induced Aβ aggregation, displays significant antioxidant activit... | |||
T61418 | BuChE-IN-6 | ||
BuChE-IN-6 (compound 1b) is a highly effective and specific inhibitor of BuChE (butyrylcholinesterase), demonstrating an IC50 value of 0.46 μM for eqBuChE and 0.51 μM for hBuChE. Furthermore, BuChE-IN-6 has the additiona... | |||
T61579 | BuChE-IN-5 | ||
BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considera... | |||
T79422 | BuChE-IN-8 | ||
BuChE-IN-8 (compound 19c), a butyrylcholinesterase (BuChE) inhibitor, exhibits an IC50 value of 559 nM and concurrently inhibits human β-secretase (BACE1) and Aβ40 aggregation. It also demonstrates notable antiamnesic pr... | |||
T60837 | AChE/BuChE-IN-2 | ||
AChE/BuChE-IN-2 (Compound 5f) can cross the BBB that is an orally active inhibitor of AChE and BuChE with IC 50 values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows potent inhibition of self-induced β-amyl... | |||
T79423 | BuChE-IN-9 | ||
BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM. In addition to eqBuChE, it also inhibits human BACE1, Aβ aggregation, and mou... | |||
T78679 | AChE/BuChE/MAO-B-IN-2 | ||
AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent inhibitor of AChE, BuChE, and hu MAO-B, with respective IC50 values of 5.3 μM, 12.4 μM, and 1.9±0.08 μM, indicating good in vitro blood-brain barrier (BBB) permeability. It... | |||
T79501 | PD10 | ||
PD10 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), exhibiting inhibitory potency at human AChE (hAChE IC50: 0.56 μM), electric eel AChE (eeAChE IC50: 0.59 μM), and equine serum BuC... | |||
T61178 | Aβ-IN-5 | ||
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor that also inhibits AChE and BuChE with IC50 values of 21.29 μM and 1.32 μM, respectively. Furthermore, Aβ-IN-5 exhibits remarkable neuroprotective effec... | |||
T79502 | PD24 | ||
PD24 serves as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with inhibitory concentrations (IC50) of 1.72 μM for human AChE (hAChE), 1.76 μM for electric eel AChE (eeAChE), and 2.64... | |||
T60940 | ChE/Aβ1-42-IN-1 | ||
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability. The IC50 values of ChE/Aβ1-42-IN-1 for AChE, BuChE and Aβ 1-42 aggregation are 0.062, 0.767 and 1.227 μM... | |||
T79503 | PD25 | ||
PD25, an inhibitor of both AChE and BuChE, demonstrates inhibitory constants of hAChE IC50: 1.58 μM, eeAChE IC50: 1.63 μM, and eqBuChE IC50: 2.39 μM. It exhibits antioxidant properties with a DPPH IC50 of 29.55 μM. This ... | |||
T79299 | HAChE-IN-3 | Monoamine Oxidase | |
hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This com... | |||
T79963 | Feralolide | ||
Feralolide, a dihydroisocoumarin from the methanolic extract of aloe vera resin, functions as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values of 55 μg/mL and 52 μg/mL, ... |