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Search Results for " brd4 inhibitor-18 "

6

Compounds

Cat No. Product Name Synonyms Targets
T63352 BRD4 Inhibitor-18 Others
BRD4 Inhibitor-18 is a potent BRD4 inhibitor (IC50: 110 nM) with a hydrophobic acetylcyclopentane side chain. BRD4 Inhibitor-18 significantly reduces the proliferation of MV-4-11 cells with high BRD4 levels, inhibits G0/...
T64089 BRD4 D1-IN-1 Others
BRD4 D1-IN-1 is a selective inhibitor of BRD4 D1 with an IC50 <0.092 μM. BRD4 D1-IN-1 has an affinity of 18 nM and over 500-fold selectivity for BRD4 D1 and BRD4 D2.
T61327 BRD4 Inhibitor-15 Others
BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD...
T15399 GNE-207 Epigenetic Reader Domain
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expres...
T78851 BRD4 Inhibitor-28 Epigenetic Reader Domain
BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55 nM, respectively. It also demonstrates inhibition of BRD2-BD...
T69815 SB-284851-BT Others
SB-284851-BT is a chemical compound that serves as an inhibitor of BRD4, p38α, and BRDT, exhibiting varying degrees of affinity and inhibition for each. Specifically, it inhibits BRD4-BD1 with an IC50 value of 1.7 µM, p3...
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