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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5099 | Gefapixant | RO 4926219,AF219,MK-7264 | P2X Receptor |
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. | |||
T3539 | Lu AF21934 | GluR | |
Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human). |