Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, including acute lung injury (ALI) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, including acute lung injury (ALI) [1]. |
In vitro | NF-κB-IN-8 (compound L26) at a concentration of 10 μM inhibits 64.30% of ALP activity [1]. Additionally, within a range of 1-10 μM for 24 hours, NF-κB-IN-8 suppresses the expression of IL-6 and TNF-α in RAW 264.7 cells [1]. At concentrations spanning from 0 to 50 μM, NF-κB-IN-8 hinders the binding of LPS to MD-2, as detected by ELISA [1]. At 50 μM, administered overnight, the compound prevents the formation of the LPS/MD-2/TLR4 complex in RAW264.7 cells [1]. |
In vivo | NF-κB-IN-8 (Compound L26), administered orally at a dose of 5 mg/kg, mitigated LPS-induced acute lung injury in mice [1]. At higher doses of 1000 and 1500 mg/kg, NF-κB-IN-8 demonstrated low toxicity and was deemed safe in mice [1]. In rats, with an administered dose of 0 mg/kg, NF-κB-IN-8 exhibited a half-life (T 1/2) of 4.2 hours and a maximum concentration (C max) of 163.288 μg/L [1]. |
Molecular Weight | 399.44 |
Formula | C24H21N3O3 |
CAS No. | 2924565-59-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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NF-κB-IN-8 2924565-59-1 NF-Κb NF-κB inhibitor inhibit