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Nω-Hydroxy-nor-L-Arginine Dihydrochloride

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Catalog No. T9096Cas No. 291758-32-2

Nω-Hydroxy-nor-L-Arginine Dihydrochloride is a competitive and reversible inhibitor of arginase

Nω-Hydroxy-nor-L-Arginine Dihydrochloride
Other Forms of Nω-Hydroxy-nor-L-Arginine Dihydrochloride:

Nω-Hydroxy-nor-L-Arginine Dihydrochloride

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Purity: 99.84%
Catalog No. T9096Cas No. 291758-32-2
Nω-Hydroxy-nor-L-Arginine Dihydrochloride is a competitive and reversible inhibitor of arginase
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$32In StockIn Stock
2 mg$46In StockIn Stock
5 mg$76In StockIn Stock
10 mg$118In StockIn Stock
25 mg$237In StockIn Stock
50 mg$353In StockIn Stock
100 mg$493In StockIn Stock
500 mgPreferential-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.84%
Color:White
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Product Introduction

Nω-Hydroxy-nor-L-Arginine Dihydrochloride AI Summary
Nω-Hydroxy-nor-L-Arginine Dihydrochloride exhibits significant inhibitory bioactivity against various arginase enzymes. It demonstrates potent inhibition of mouse macrophage arginase with an IC50 value of 50,000 nM and rat liver arginase with an IC50 value of 2,000 nM. It also inhibits bovine liver arginase, reducing urea production from L-arginine, with an IC50 value of 1,700 nM assessed through spectrophotometric analysis. For human recombinant ARG1, it shows an IC50 of 450 nM and binds with high affinity, having a Kd value of 47 nM. Additionally, Nω-Hydroxy-nor-L-Arginine Dihydrochloride inhibits human ARG2 with a Ki value of 51 nM. In rat models, the compound exhibits a half-life of 0.25 hours and 100% oral bioavailability. It effectively inhibits human ARG1 with IC50 values ranging from 1,360 nM to 2000 nM and exhibits binding affinities varying in different pH conditions. These characteristics suggest its potential as a therapeutic enzyme inhibitor targeting various forms of arginase..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Nω-Hydroxy-nor-L-Arginine Dihydrochloride is a competitive and reversible inhibitor of arginase
Chemical Properties
Molecular Weight249.10
FormulaC5H14Cl2N4O3
Cas No.291758-32-2
SmilesCl.Cl.N[C@@H](CCNC(=N)NO)C(O)=O
Relative Density.no data available
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 1.76 mg/mL (7.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.0145 mL20.0723 mL40.1445 mL200.7226 mL
5 mM0.8029 mL4.0145 mL8.0289 mL40.1445 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nω-Hydroxy-nor-L-Arginine DihydrochlorideNωHydroxynorLArginine DihydrochlorideNω-Hydroxy-nor-L-ArginineNω Hydroxy nor L Arginine DihydrochlorideNw-Hydroxy-nor-L-Arginine DihydrochlorideNw-Hydroxy-nor-L-ArginineNomega-Hydroxy-nor-L-Arginine DihydrochlorideNomega-Hydroxy-nor-L-Argininearginase
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