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JQ-1 (carboxylic acid)

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Catalog No. T5443Cas No. 202592-23-2
Alias JQ-1 carboxylic acid

JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)

JQ-1 (carboxylic acid)
Other Forms of JQ-1 (carboxylic acid):

JQ-1 (carboxylic acid)

🥰Excellent
Purity: 99.9%
Catalog No. T5443Alias JQ-1 carboxylic acidCas No. 202592-23-2
JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$64In StockIn Stock
10 mg$80In StockIn Stock
25 mg$123In StockIn Stock
50 mg$163In StockIn Stock
100 mg$247In StockIn Stock
200 mg$372-In Stock
1 mL x 10 mM (in DMSO)$70In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.9%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)
Targets&IC50
BRD4(2):33 nM, BRD4(1):77 nM
In vitro
JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins, blocking their interaction with acetylated histones[1],it has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis[2][3].
SynonymsJQ-1 carboxylic acid
Chemical Properties
Molecular Weight400.88
FormulaC19H17ClN4O2S
Cas No.202592-23-2
SmilesCC=1C2=C(N3C([C@H](CC(O)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C
Relative Density.1.51 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 12.5 mg/mL (31.18 mM), Sonication is recommended.
DMSO: 155 mg/mL (386.65 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.98 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4945 mL12.4726 mL24.9451 mL124.7256 mL
5 mM0.4989 mL2.4945 mL4.9890 mL24.9451 mL
10 mM0.2495 mL1.2473 mL2.4945 mL12.4726 mL
20 mM0.1247 mL0.6236 mL1.2473 mL6.2363 mL
DMSO
1mg5mg10mg50mg
50 mM0.0499 mL0.2495 mL0.4989 mL2.4945 mL
100 mM0.0249 mL0.1247 mL0.2495 mL1.2473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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