keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hemopressin TFA, a nonapeptide originating from the α1-chain of hemoglobin and initially isolated from rat brain homogenates, is an orally active, selective inverse agonist of CB1 cannabinoid receptors that demonstrates antinociceptive effects in inflammatory pain models [1] [2].
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Description | Hemopressin TFA, a nonapeptide originating from the α1-chain of hemoglobin and initially isolated from rat brain homogenates, is an orally active, selective inverse agonist of CB1 cannabinoid receptors that demonstrates antinociceptive effects in inflammatory pain models [1] [2]. |
In vivo | Hemopressin TFA induces hypotension in anesthetized rats and undergoes metabolism by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE) in both in vivo and in vitro conditions [1]. When administered orally, it mitigates mechanical hyperalgesia in CCI-rats for up to 6 hours and reduces Egr-1 immunoreactivity (Egr-1Ir) in the dorsal horn's superficial layer within the spinal cord of CCI rats [2]. |
Molecular Weight | 1168.27 |
Formula | C52H80F3N13O14 |
CAS No. | 1431329-48-4 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Hemopressin(human, mouse) TFA 1431329-48-4 GPCR/G Protein Cannabinoid Receptor inhibitor inhibit