DDR1 Protein, Human, Recombinant (aa 21-417, His)

Name: DDR1 Protein, Human, Recombinant (aa 21-417, His)
Brand: TargetMol
SKU: TMPH-01297
Rating: 4.5 (1 reviews)

(Synonyms: Tyrosine-protein kinase CAK, Tyrosine kinase DDR, TRKE, TRK E, RTK6, PTK3A, Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, NEP, Mammary carcinoma kinase 10 (MCK-10), HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, Discoidin receptor tyrosine kinase, DDR1, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CAK) Copy Product Info

Synonyms: Tyrosine-protein kinase CAK, Tyrosine kinase DDR, TRKE, TRK E, RTK6, PTK3A, Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, NEP, Mammary carcinoma kinase 10 (MCK-10), HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, Discoidin receptor tyrosine kinase, DDR1, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CAK

Catalog No. TMPH-01297 Copy Product Info

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Pack Size	Price	USA Stock	Global Stock
5 μg	$43	20 days	20 days
10 μg	$66	20 days	20 days
20 μg	$106	20 days	20 days
50 μg	$189	20 days	20 days
100 μg	$297	20 days	20 days
200 μg	$519	20 days	20 days
500 μg	$1,090	20 days	20 days
1 mg	$1,930	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity


Description	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Species	Human
Expression System	HEK293 Cells
Tag	C-10xHis
Accession Number	Q08345
Amino Acid	DMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTA
Construction	21-417 aa
Protein Purity	> 95% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Synonyms	Tyrosine-protein kinase CAK, Tyrosine kinase DDR, TRKE, TRK E, RTK6, PTK3A, Protein-tyrosine kinase RTK-6, Protein-tyrosine kinase 3A, NTRK4, NEP, Mammary carcinoma kinase 10 (MCK-10), HGK2, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, EDDR1, Discoidin receptor tyrosine kinase, DDR1, Cell adhesion kinase, CD167a, CD167 antigen-like family member A, CAK
Research Background

Chemical Properties

Molecular Weight

46.8 kDa (predicted)

Storage & Solubility Information

Storage

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TRK-ERTK 6NTRK 4MCK-10MCK10HGK 2EDDR 1DDR 1

Related Tags: DDR1 Protein, Human, Recombinant (aa 21-417, His) chemical structure | DDR1 Protein, Human, Recombinant (aa 21-417, His) molecular weight