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coagulation factor II (thrombin) B chain fragment [Homo sapiens]

Catalog No. TP2234 CAS TP2234

Thrombin is a "trypsin-like" serine protease that is encoded by the F2 gene in humans. Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin. Thrombin is also active in the catalysis of many other coagulation-related reactions.

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coagulation factor II (thrombin) B chain fragment [Homo sapiens] Chemical Structure

coagulation factor II (thrombin) B chain fragment [Homo sapiens], CAS TP2234

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Thrombin is implicated as a major factor in vasospasm following subarachnoid hemorrhage. Blood from a ruptured cerebral aneurysm clot around a cerebral artery, releasing thrombin. This can induce an acute and prolonged narrowing of the blood vessel, potentially resulting in cerebral ischemia and infarction (stroke). Beyond its key role in the dynamic process of thrombus formation, thrombin has a pronounced pro-inflammatory character, which may influence the onset and progression of atherosclerosis [2][3].

Molecular Weight	1957.26
Formula	C90H137N23O24S
CAS No.	TP2234

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≥195.7mg/mL

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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coagulation factor II (thrombin) B chain fragment [Homo sapiens] TP2234 Others inhibitor inhibit

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