Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | Inquiry | $ 325.00 |
Description | C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml. |
Synonyms | C8 D-threo Ceramide (d18:1/8:0) |
Molecular Weight | 425.698 |
Formula | C26H51NO3 |
CAS No. | 175892-43-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Soluble
Chloroform: Soluble
DMSO: Soluble
DMF: Soluble
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