Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zorubicin (Rubidazon), a Daunorubicin derivative, inhibits DNA polymerases and interacts with topoisomerase II. It is utilized in the research of acute leukemias and sarcomas [1] [2] [3] [4] [5].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 4,520.00 | |
50 mg | 10-14 weeks | $ 5,980.00 | |
100 mg | 10-14 weeks | $ 8,500.00 |
Description | Zorubicin (Rubidazon), a Daunorubicin derivative, inhibits DNA polymerases and interacts with topoisomerase II. It is utilized in the research of acute leukemias and sarcomas [1] [2] [3] [4] [5]. |
In vitro |
H2-Gamendazole (H2-GMZ; 0-100 μM) was effective in rapidly blocking forskolin-induced, Cl-mediated short-circuit currents in human ADPKD cells, and it significantly inhibited both cAMP- and epidermal growth factor-induced proliferation of ADPKD cells.[1] H2-GMZ (50 μM)-treated ADPKD cells showed decreased phosphorylated ERK and decreased hyperphosphorylated retinoblastoma levels through western blot analysis.[1] H2-GMZ (50 μM; 24、48、72 h) treatment also decreased ErbB2, Akt, and cyclin-dependent kinase 4 and it decreased levels of the cystic fibrosis transmembrane conductance regulator Cl channel protein.[1] |
In vivo | H2-Gamendazole (20 mg/kg; intraperitoneal injections) was effective in slowing postnatal cyst formation and kidney enlargement in the ---Pkd1flox/flox: Pkhd1-Cre mouse model.[1] |
Synonyms | Rubidazon ; Rubidazone, Rubidazone, Rubidazon |
Molecular Weight | 645.66 |
Formula | C34H35N3O10 |
CAS No. | 54083-22-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Zorubicin 54083-22-6 MCMC-4222 RP 22050 Rubidazon ; Rubidazone MCMC4222 Rubidazone RP22050 MCMC 4222 Rubidazon ; Rubidazone Zorubicine. Rubidazone Rubidazon RP-22050 inhibitor inhibit