Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
Description | Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL). |
Targets&IC50 | S. aureus:0.25 μg/mL (MIC90) |
In vitro | Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA. |
Synonyms | AZD0914, ETX0914 |
Molecular Weight | 487.44 |
Formula | C22H22FN5O7 |
CAS No. | 1620458-09-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 135 mg/mL (276.95 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zoliflodacin 1620458-09-4 DNA损伤和修复 微生物学 细胞周期 Antibacterial DNA gyrase DNA/RNA Synthesis Topoisomerase ETX 0914 AZD0914 Inhibitor ETX-0914 AZD-0914 Bacterial inhibit AZD 0914 ETX0914 inhibitor