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Zoliflodacin

Catalog No. TQ0063 CAS 1620458-09-4

Synonyms: AZD0914, ETX0914

Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).

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Zoliflodacin, CAS 1620458-09-4

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Zoliflodacin (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
Targets&IC50	S. aureus:0.25 μg/mL (MIC90)
In vitro	Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.

Synonyms	AZD0914, ETX0914
Molecular Weight	487.44
Formula	C22H22FN5O7
CAS No.	1620458-09-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 135 mg/mL (276.95 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huband MD, et al. In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria. Antimicrob Agents Chemother. 2015 Jan;59(1):467-74.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Antibiotics Library Inhibitor Library DNA Damage & Repair Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Bacterial Compound Library Bioactive Compound Library Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zoliflodacin 1620458-09-4 DNA损伤和修复微生物学细胞周期 Antibacterial DNA gyrase DNA/RNA Synthesis Topoisomerase ETX 0914 AZD0914 Inhibitor ETX-0914 AZD-0914 Bacterial inhibit AZD 0914 ETX0914 inhibitor

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