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Zafirlukast

Catalog No. T6736 CAS 107753-78-6

Synonyms: Accolate, 扎鲁司特, ICI 204219, Vanticon

Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma.

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Zafirlukast, CAS 107753-78-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma.

Synonyms	Accolate, 扎鲁司特, ICI 204219, Vanticon
Molecular Weight	575.68
Formula	C31H33N3O6S
CAS No.	107753-78-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 93 mg/mL (161.5 mM)

Ethanol: <1 mg/mL

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kassahun K, et al. Chem Res Toxicol,2005, 18(9), 1427-1437. 2. Mahgoub AA, et al. Toxicol Lett,2003, 145(1), 79-87. 3. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease[J]. Bioorganic chemistry. 2019 Mar;84:87-97.

Citations

1. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease. Bioorganic Chemistry. 2019 Mar;84:87-97 2. Zhang S, Gao C, Das T, et al. The spike-ACE2 binding assay: An in vitro platform for evaluating vaccination efficacy and for screening SARS-CoV-2 inhibitors and neutralizing antibodies. Journal of Immunological Methods. 2022: 113244.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library GPCR Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library PPI Inhibitor Library

Related Products

Related compounds with same targets

Zafirlukast 5-O-Demethylnobiletin MK-571 sodium CGP 35949 ABT-080 L 674573 SR 2640 hydrochloride LY255283

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zafirlukast 107753-78-6 G蛋白偶联受体 Leukotriene Receptor Accolate ICI-204219 ICI 204219 Inhibitor inhibit ICI204219 Vanticon inhibitor

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