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ZM323881 hydrochloride

ZM323881 hydrochloride
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ZM323881 hydrochloride

Catalog No. T1991Cas No. 193000-39-4
ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$66In Stock
10 mg$103In Stock
25 mg$249In Stock
50 mg$426In Stock
1 mL x 10 mM (in DMSO)$66In Stock
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Product Introduction

ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.
In vivo
At concentrations below 1 μM, ZM323881 inhibits the proliferation of neural stem cells stimulated by VEGF in a dose-dependent manner. It impedes the activation of extracellular signal-regulated kinase, p38, Akt, and endothelial nitric oxide synthase (eNOS) through VEGF blockade at 1 μM, without suppressing the expression of the VEGFR-1 specific ligand, placental growth factor (PlGF), in human aortic endothelial cells (HAECs). Additionally, 1 μM ZM323881 disrupts VEGF-induced membrane extension, cell migration, and tube formation in HAECs and reverses the phosphorylation of CrkII and its SRC homology 2 domain-binding protein p130Cas, key in regulating endothelial cell migration. ZM323881 inhibits the proliferation of HUVEC cells induced by VEGF-A, EGF, and bFGF, with IC50 values of 8 nM, 1.9 μM, and 1.6 μM respectively. At 10 nM, ZM323881 eradicates the increase in vascular permeability mediated by VEGF-A in the mesenteric microvasculature of male leopards. Furthermore, 10 nM ZM323881 completely obstructs VEGF-induced promoter activity and Hif-1α protein accumulation in VEGF-stimulated SCC-9 cells.
AliasZM 323881 hydrochloride, ZM 323881 HCl
Chemical Properties
Molecular Weight411.86
Cas No.193000-39-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 20.6 mg/mL (50 mM)
Solution Preparation Table
1 mM2.4280 mL12.1400 mL24.2801 mL121.4005 mL
5 mM0.4856 mL2.4280 mL4.8560 mL24.2801 mL
10 mM0.2428 mL1.2140 mL2.4280 mL12.1400 mL
20 mM0.1214 mL0.6070 mL1.2140 mL6.0700 mL


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Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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