Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 66.00 | |
10 mg | In stock | $ 103.00 | |
25 mg | In stock | $ 249.00 | |
50 mg | In stock | $ 426.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 66.00 |
Description | ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor. |
Targets&IC50 | VEGFR2:<2 nM |
In vivo | At concentrations below 1 μM, ZM323881 inhibits the proliferation of neural stem cells stimulated by VEGF in a dose-dependent manner. It impedes the activation of extracellular signal-regulated kinase, p38, Akt, and endothelial nitric oxide synthase (eNOS) through VEGF blockade at 1 μM, without suppressing the expression of the VEGFR-1 specific ligand, placental growth factor (PlGF), in human aortic endothelial cells (HAECs). Additionally, 1 μM ZM323881 disrupts VEGF-induced membrane extension, cell migration, and tube formation in HAECs and reverses the phosphorylation of CrkII and its SRC homology 2 domain-binding protein p130Cas, key in regulating endothelial cell migration. ZM323881 inhibits the proliferation of HUVEC cells induced by VEGF-A, EGF, and bFGF, with IC50 values of 8 nM, 1.9 μM, and 1.6 μM respectively. At 10 nM, ZM323881 eradicates the increase in vascular permeability mediated by VEGF-A in the mesenteric microvasculature of male leopards. Furthermore, 10 nM ZM323881 completely obstructs VEGF-induced promoter activity and Hif-1α protein accumulation in VEGF-stimulated SCC-9 cells. |
Synonyms | ZM 323881 hydrochloride, ZM 323881 HCl |
Molecular Weight | 411.86 |
Formula | C22H19ClFN3O2 |
CAS No. | 193000-39-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20.6 mg/mL (50 mM)
You can also refer to dose conversion for different animals. More
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ZM323881 hydrochloride 193000-39-4 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors FGFR VEGFR EGFR PDGFR ZM 323881 Hydrochloride ZM-323881 Hydrochloride ZM323881 Inhibitor ZM 323881 ZM 323881 hydrochloride Vascular endothelial growth factor receptor ZM-323881 hydrochloride inhibit ZM-323881 ZM 323881 HCl ZM323881 Hydrochloride inhibitor