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ZM 306416

Name: ZM 306416
Brand: TargetMol
SKU: T1754
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1754Cas No. 690206-97-4

Alias CB 676475

ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).

ZM 306416

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Purity: 99.88%

Catalog No. T1754Alias CB 676475Cas No. 690206-97-4

ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$197	In Stock	In Stock
100 mg	$313	In Stock	In Stock
200 mg	$467	In Stock	-
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

ZM 306416 AI Summary

ZM 306416 exhibits a range of bioactivities across multiple targets and assays. It inhibits vascular endothelial growth factor receptor (VEGFR) pathways with IC50 values of 2000.0 nM for VEGFR1 and 100.0 nM for VEGFR2 in vitro. Additionally, it inhibits FGFR-1 with an IC50 of 7000.0 nM and demonstrates 34.0% inhibition of VEGF-mediated estradiol benzoate-induced rat uterus weight gain at a 100 mg/kg oral dose. The compound has selectivities of 4.0 for FGFR-1 to VEGFR1 and 70.0 for FGFR-1 to VEGFR2. In the context of EphB2 receptor tyrosine kinase, ZM 306416 has a Kd of 6200.0 nM and IC50 of 8500.0 nM. It also shows variable inhibitory activities on VEGFR1 in different cellular assays, with IC50 values ranging from 14100.0 nM to 17700.0 nM. Furthermore, ZM 306416 displays antiviral activity against SARS-CoV-2, with notable cytotoxicity inhibition in Caco-2 and VERO-6 cells at 10 µM concentrations, but less pronounced inhibition of the SARS-CoV-2 3CL-Pro protease. It also demonstrates modest inhibitory activity on the human HDAC6 enzyme, showing 10.1% inhibition with a commercial peptide substrate and 4.92% with a custom peptide substrate. These results collectively highlight the compound's potential as a multi-target inhibitor with applications in oncology and virology..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).
Targets&IC50	KDR:100 nM, VEGFR1:0.33 μM, EGFR:<10 nM, FLT1:2 μM
In vivo	When acting on human thyroid follicular cells, ZM306416 (1 μM) decreased nuclear distribution and increased follicle formation; a significant increase in cell death was observed at 3 μM.ZM306416 weakly inhibited VEGF secretion and increased PlGF production.ZM306416 (<10 μM) had a significant inhibitory effect on steady-state phosphorylation of p42/44 MAPK but had no effect on the non phosphorylated forms, but had no effect on the expression of non-phosphorylated forms. In human thyroid follicular cells, ZM306416 (300 nM) completely inhibited PAA secretion, stimulated [125I] uptake, and silenced pVEGFR2 (Y1214) expression. ZM-306416 exhibited selective antiproliferative effects (IC50: 0.09 μM and 0.072 μM) when acting on the epidermal growth factor receptor-naïve non-small cell (type) lung cancer cell lines H3255 and HCC4011. When acting on GeneBLAzer T-Rex RORγ-UAS-bla HEK293T cell line, ZM-306416 had a significant inhibitory effect on ERRα assay (IC50: 7.3 μM).ZM-306416 inhibited granule formation (IC50: 0.67 μM).
Synonyms	CB 676475

Chemical Properties

Molecular Weight	333.74
Formula	C₁₆H₁₃ClFN₃O₂
Cas No.	690206-97-4
Smiles	COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC
Relative Density.	1.389 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62 mg/mL (185.77 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9963 mL	14.9817 mL	29.9634 mL	149.8172 mL
5 mM	0.5993 mL	2.9963 mL	5.9927 mL	29.9634 mL
10 mM	0.2996 mL	1.4982 mL	2.9963 mL	14.9817 mL
20 mM	0.1498 mL	0.7491 mL	1.4982 mL	7.4909 mL
50 mM	0.0599 mL	0.2996 mL	0.5993 mL	2.9963 mL
100 mM	0.0300 mL	0.1498 mL	0.2996 mL	1.4982 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc