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ZM 306416

Catalog No. T1754   CAS 690206-97-4
Synonyms: CB 676475

ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).

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ZM 306416 Chemical Structure
ZM 306416, CAS 690206-97-4
Pack Size Availability Price/USD Quantity
2 mg In stock $ 39.00
5 mg In stock $ 55.00
10 mg In stock $ 100.00
25 mg In stock $ 208.00
50 mg In stock $ 393.00
100 mg In stock $ 585.00
1 mL * 10 mM (in DMSO) In stock $ 55.00
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Purity: 99.31%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ZM 306416 (CB 676475), a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).
Targets&IC50 EGFR:<10 nM, VEGFR1:0.33 μM
Synonyms CB 676475
Molecular Weight 333.74
Formula C16H13ClFN3O2
CAS No. 690206-97-4


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62 mg/mL (185.8 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Antczak C, et al. J Biomol Screen, 2012, 17(7), 885-899. 2. Wilkinson J, et al. Assay Drug Dev Technol. 2011 Apr;9(2):125-35. 3. Susarla R, et al. Mol Cell Endocrinol, 2012, 351(2), 199-207. 4. Susarla R, et al. J Cell Physiol, 2012, 227(5), 11992-22002.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Tyrosine Kinase Inhibitor Library Membrane Protein-targeted Compound Library Kinase Inhibitor Library Anti-Liver Cancer Compound Library NO PAINS Compound Library Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Anti-Cardiovascular Disease Compound Library Anti-Pancreatic Cancer Compound Library

Related Products

Related compounds with same targets
Capillarisin Sunitinib TG 100801 Nintedanib esylate VEGFR-2-IN-33 MAZ51 SU4312 AMG-47a

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.


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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


ZM 306416 690206-97-4 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl Src VEGFR ZM-306416 Inhibitor CB-676475 CB676475 inhibit CB 676475 ZM306416 Vascular endothelial growth factor receptor inhibitor