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Ximoprofen

Catalog No. T35180 CAS 56187-89-4

Synonyms: Ximoprofeno, Ximoprofenum

Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.

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Ximoprofen, CAS 56187-89-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 373.00
5 mg	In stock	$ 896.00
10 mg	In stock	$ 1,230.00
25 mg	In stock	$ 1,820.00
50 mg	In stock	$ 2,450.00
100 mg	In stock	$ 3,290.00

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Purity: 98.27%

Biological Description

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Storage & Solubility Information

Description

Ximoprofen is a novel anti-inflammatory compound for the study of spondylitis.

In vivo

The aim of the study was to evaluate the efficacy of different daily dosages of Ximoprofen in patients with active ankylosing spondylitis. For 2 weeks 5 parallel groups were studied: placebo and Ximoprofen at 5, 10, 20, and 30 mg daily. Response to treatment was defined as an improvement in pain (VAS 100 mm) of at least 50% during the study. At the end of the study, the percentage of responders was higher in the Ximoprofen groups (54%, 41%, 53%, 56% in the 5, 10, 20, and 30 mg groups, respectively) than in the placebo group (21%). The clearest dose-related effect of Ximoprofen observed occurred after one week of treatment. This study 1/confirms the efficacy of Ximoprofen at a 30 mg daily dosage, 2/shows the persistence of this efficacy at lower dosages, 3/suggests that ankylosing spondylitis is a sensitive and relevant human model to assess NSAIDs at an early stage of clinical evaluation.[1]

Synonyms	Ximoprofeno, Ximoprofenum
Molecular Weight	261.32
Formula	C15H19NO3
CAS No.	56187-89-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (191.34 mM)

References and Literature

1. Dougados M, et al. Ximoprofen in ankylosing spondylitis. A double blind placebo controlled dose ranging study. Scand J Rheumatol. 1994;23(5):243-8. 2. Taylor IW, et al. Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy young and elderly subjects: comparison with elderly rheumatic patients. Br J Clin Pharmacol. 1991 Aug;32(2):242-5. 3. Taylor IW, et al. Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy subjects and in disease states. Eur J Clin Pharmacol. 1991;40(1):101-6. 4. Morris GR, et al. Determination of ximoprofen and its metabolites in human urine by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr. 1990 Sep 14;530(2):377-85.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Ximoprofen 56187-89-4 Others Ximoprofeno Ximoprofenum inhibitor inhibit

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