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XEN723

Name: XEN723
Brand: TargetMol
SKU: T13356
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13356Cas No. 1072803-08-7

XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).

XEN723

🥰Excellent

Purity: 99.5%

Catalog No. T13356Cas No. 1072803-08-7

XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$118	In Stock
10 mg	$188	In Stock
25 mg	$320	In Stock
50 mg	$461	In Stock
100 mg	$648	In Stock
200 mg	$873	In Stock
1 mL x 10 mM (in DMSO)	$142	In Stock

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Batch Information

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Purity:99.5%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
Targets&IC50	SCD1:524 nM( in HepG2 cell), SCD1:45 nM(in Mouse)
In vitro	XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively). XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit.

Chemical Properties

Molecular Weight	425.48
Formula	C₂₁H₂₀FN₅O₂S
Cas No.	1072803-08-7
Smiles	Cc1nc(sc1C(=O)NCc1cccnc1)N1CCN(Cc2ccc(F)cc2)C1=O
Relative Density.	1.384 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (235.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3503 mL	11.7514 mL	23.5029 mL	117.5143 mL
5 mM	0.4701 mL	2.3503 mL	4.7006 mL	23.5029 mL
10 mM	0.2350 mL	1.1751 mL	2.3503 mL	11.7514 mL
20 mM	0.1175 mL	0.5876 mL	1.1751 mL	5.8757 mL
50 mM	0.0470 mL	0.2350 mL	0.4701 mL	2.3503 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1751 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc