Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 396.00 | |
5 mg | In stock | $ 822.00 | |
10 mg | In stock | $ 1,130.00 | |
25 mg | In stock | $ 1,690.00 | |
50 mg | In stock | $ 2,290.00 |
Description | SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells). |
Targets&IC50 | NF-κB:, NF-κB-luc:122 nM (in HAECT-1 cell) |
In vitro | SIM-688 displaces [3H]E2 from the ERα ligand-binding domain protein (C50=2.43 μM) and from the ERβ ligand-binding domain protein (IC50=1.5 μM)[1]. |
In vivo | SIM-688 (5 mg/kg per day, p.o.) inhibits pro-inflammatory genes including MHI, VCAM-1, RANTES, and TNF-α and induces the gene products and uterine wet weight. SIM-688 (0.3 mg/kg, p.o.) is active in the Lewis rat adjuvant-induced arthritis model [1]. |
Synonyms | SIM688 |
Molecular Weight | 556.62 |
Formula | C34H31F3N2O2 |
CAS No. | 796854-35-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (161.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SIM-688 796854-35-8 Endocrinology/Hormones NF-Κb Estrogen/progestogen Receptor NF-κB SIM 688 SIM688 inhibitor inhibit