Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag) in cystic fibrosis, and modification of CFTR by small molecule modulator VRT-532 can increase ARSB and reduce the accumulation of 4-chondroitin sulfate.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 329.00 | |
5 mg | In stock | $ 798.00 | |
10 mg | In stock | $ 1,090.00 | |
25 mg | In stock | $ 1,650.00 | |
50 mg | In stock | $ 2,230.00 | |
100 mg | In stock | $ 2,930.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 797.00 |
Description | VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glycosaminosaccharide (gag) in cystic fibrosis, and modification of CFTR by small molecule modulator VRT-532 can increase ARSB and reduce the accumulation of 4-chondroitin sulfate. |
In vitro | VRT-532 binds directly to G551D-CFTR in isolated systems, thereby improving its channel function and increasing its ATPase rate. VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR[1]. |
Synonyms | CFpot-532, CFpot-532) |
Molecular Weight | 250.3 |
Formula | C16H14N2O |
CAS No. | 38214-71-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mg/mL (27.39 mM)
You can also refer to dose conversion for different animals. More
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VRT-532 38214-71-0 Membrane transporter/Ion channel CFTR VRT532 CFpot-532 VRT 532 CFpot-532) inhibitor inhibit