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Urocortin, rat TFA (171543-83-2 free base)

Catalog No. TP2159 CAS TP2159

Synonyms: Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA, Urocortin, rat TFA

Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).

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Urocortin, rat TFA (171543-83-2 free base) Chemical Structure

Urocortin, rat TFA (171543-83-2 free base), CAS TP2159

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Description	Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
Targets&IC50	CRF2α (rat):1.5 nM (ki), CRF2β (mouse):0.97 nM (ki), CRF1 (human):ki： 13 nM
In vitro	In stably transfected Chinese hamster ovary cells, Urocortin, rat induces cAMP generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α, and mouse CRF2β, respectively [2].
In vivo	Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat (i.c.v.). It has the potential of inducing anxiogenic behavior [3].

Synonyms	Urocortin (Rattus norvegicus) (TFA), Rat urocortin TFA, Urocortin, rat TFA
Molecular Weight	4821.28
Formula	C208H339N62F3O66
CAS No.	TP2159

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Perrin MH, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28. 2. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. 3. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.

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Keywords

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