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UNC 569 hydrochloride

UNC 569 hydrochloride
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Purity:100%
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UNC 569 hydrochloride

Catalog No. T21302L
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydrochloride can be used in studies about acute lymphoblastic leukemia and atypical teratoid/rhabdoid tumors.
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Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$39In Stock
5 mg$58In Stock
10 mg$98In Stock
25 mg$219In Stock
50 mg$352In Stock
100 mg$493In Stock
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Product Introduction

Bioactivity
Description
UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydrochloride can be used in studies about acute lymphoblastic leukemia and atypical teratoid/rhabdoid tumors.
In vitro
UNC 569 hydrochloride inhibits Mer phosphorylation levels with IC50 values of 141 nM and 193 nM in human B-ALL 697 and Jurkat cell lines, respectively. UNC 569 hydrochloride (1 µM) treatment effectively inhibits the activation of Mer and downstream signaling, including the PI3K/AKT and MAPK/ERK pathways. In ALL cell lines, UNC 569 hydrochloride (0.4 -2 µM) induces apoptosis and increases the levels of cleaved Caspase 3 and cleaved PARP[1].
In vivo
In Leukemic zebrafish, UNC 569 hydrochloride (4 µM) induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish[1]. UNC 569 hydrochloride has low systemic clearance (19.5 mL/min/kg), high volume of distribution (Vss of 5.83 L/kg), and good oral bioavailability (57%)[2].
AliasUNC 569 hydrochloride (1350547-65-7 Free base)
Chemical Properties
Molecular Weight432.96
FormulaC22H30ClFN6
Cas No.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 3.61 mg/mL (8.34 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3097 mL11.5484 mL23.0968 mL115.4841 mL
5 mM0.4619 mL2.3097 mL4.6194 mL23.0968 mL

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