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UNC7467

Catalog No. T60164 CAS T60164

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol phosphates. UNC7467 can be used for obesity research [1].

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UNC7467, CAS T60164

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 455.00
50 mg	In stock	$ 672.00
100 mg	In stock	$ 956.00
500 mg	In stock	$ 1,920.00

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Purity: 99.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates without significantly perturbing levels of other inositol phosphates. UNC7467 can be used for obesity research [1].
In vitro	UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces inositol pyrophosphates levels. UNC7467 reduces 5-InsP 7 levels by 81% and 5-InsP 8 levels by 63% [1].
In vivo	UNC7467, administered at a dosage of 5 mg/kg through intraperitoneal injection daily for 4 weeks, significantly ameliorated diet-induced obesity, insulin resistance, and hepatic steatosis in mice with diet-induced obesity (DIO). This compound also demonstrated considerable pharmacokinetic benefits in DIO mice, presenting a low clearance rate of 13.7 (mL/min)/kg and yielding substantial area under the curve (AUC) values of 6054 h ng/mL for intravenous (i.v.) and 2527 h ng/mL for intraperitoneal (i.p.) routes at a 5 mg/kg dose. Furthermore, it improved glycemic profiles, mitigated hepatic steatosis, and curbed weight gain without affecting the mice's food intake. These findings underscore UNC7467's potential as an efficacious agent for treating diet-induced obesity and related metabolic disorders.

Molecular Weight	315.32
Formula	C20H13NO3
CAS No.	T60164

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.15 mg/mL (10 mM)

References and Literature

1. Zhou Y, et, al. Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. J Med Chem. 2022 May 12;65(9):6869-6887.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Bioactive Compound Library Anti-Obesity Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC7467 T60164 Others UNC 7467 UNC-7467 inhibitor inhibit

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