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UNC2025 2HCl (1429881-91-3(free base))

Catalog No. T4419 CAS T4419

UNC2025 is a potent and orally bioavailable Mer/<a href="/target/FLT" style="display: inline; color: #c13a36">FLT</a>3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/<a href="/target/FLT" style="display: inline; color: #c13a36">FLT</a>3.

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UNC2025 2HCl (1429881-91-3(free base)), CAS T4419

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 74.00
5 mg	In stock	$ 102.00
10 mg	In stock	$ 175.00
25 mg	In stock	$ 340.00
50 mg	In stock	$ 598.00
1 mL * 10 mM (in DMSO)	In stock	$ 175.00

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Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
Targets&IC50	FLT3:0.74 nM, Mer:0.8 nM
In vivo	UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow.

Molecular Weight	549.62
Formula	C28H42Cl2N6O
CAS No.	T4419

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 6.66 mg/mL, Need ultrasonic; in vivo:dissolved in DMSO and then diluted with water (DMSO:water=1:6)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhang W,etal.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.J Med Chem. 2014 Aug 28;57(16):7031-41.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Lung Cancer Compound Library Angiogenesis related Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Anti-COVID-19 Compound Library Bioactive Compound Library Orally Active Compound Library NO PAINS Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

DS-1205 ONO-7475 2-D08 NPS-1034 Pralatrexate S49076 HCl S49076 UNC 569 hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC2025 2HCl (1429881-91-3(free base)) T4419 Angiogenesis Tyrosine Kinase/Adaptors TAM Receptor FLT UNC-2025 2HCl (1429881-91-3(free base)) UNC2025 2HCl (1429881913(free base)) UNC2025 2HCl (1429881 91 3(free base)) Inhibitor inhibitor inhibit

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