Powder: -20°C for 3 years
In solvent: -80°C for 2 years
UNC2025 is a potent and orally bioavailable Mer/<a href="/target/FLT" style="display: inline; color: #c13a36">FLT</a>3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/<a href="/target/FLT" style="display: inline; color: #c13a36">FLT</a>3.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 102.00 | |
10 mg | In stock | $ 175.00 | |
25 mg | In stock | $ 340.00 | |
50 mg | In stock | $ 598.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 175.00 |
Description | UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3. |
Targets&IC50 | FLT3:0.74 nM, Mer:0.8 nM |
In vivo | UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. |
Molecular Weight | 549.62 |
Formula | C28H42Cl2N6O |
CAS No. | T4419 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 6.66 mg/mL, Need ultrasonic; in vivo:dissolved in DMSO and then diluted with water (DMSO:water=1:6)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UNC2025 2HCl (1429881-91-3(free base)) T4419 Angiogenesis Tyrosine Kinase/Adaptors TAM Receptor FLT UNC-2025 2HCl (1429881-91-3(free base)) UNC2025 2HCl (1429881913(free base)) UNC2025 2HCl (1429881 91 3(free base)) Inhibitor inhibitor inhibit