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UNC 669

Catalog No. T2252 CAS 1314241-44-5

Synonyms: UNC669

UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

UNC 669, CAS 1314241-44-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 48.00
25 mg	In stock	$ 79.00
50 mg	In stock	$ 111.00
100 mg	In stock	$ 198.00
1 mL * 10 mM (in DMSO)	In stock	$ 32.00

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Purity: 97.40%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
Targets&IC50	L3MBTL1:4.2 μM, L3MBTL3:3.1 μM
Kinase Assay	In vitro Enzyme Assays.: All in vitro enzyme assays are done at Upstate Biotechnology with the exception of InsR and IGF-1R. To determine the IC50 of TAE684 against InsR and IGF-1R a homogeneous time-resolved fluorescence assay is performed. ATP (10 mM) and 20 mg/ml biotinylated PolyEY (Glu, Tyr 4:1) are combined with 50 nL of serial dilutions of TAE684 (10-500 nM) and 4 ng of InsR enzyme in the presence of the kinase reaction buffer (20 mM Tris譎Cl, pH 7.5/10 mM MgCl2/3 mM MnCl2/1 mM DTT/10 mM NaVO4/0.1 mg/ml of BSA). Assays are incubated for 1 hour at ambient temperature. Reactions are terminated by adding 10 mL of the detection solution containing 50 mM EDTA, 500 mM KF, 0.5 mg/ml of BSA, 5 mg/mL Eu3+ cryptate-labeled anti-phosphotyrosine antibody Mab PT66-K, and 5 mg/mL Streptavidin-XLent. The reaction is incubated for half an hour, and fluorescence signals are read on Analyst GT.

Synonyms	UNC669
Molecular Weight	338.24
Formula	C15H20BrN3O
CAS No.	1314241-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (26.6 mM)

Ethanol: 63 mg/mL (186.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Herold JM, et al. J Med Chem. 2011, 54(7), 2504-2511.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Epigenetics Compound Library Anti-Aging Compound Library Reprogramming Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Histone Modification Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UNC 669 1314241-44-5 Chromatin/Epigenetic Epigenetic Reader Domain UNC669 UNC-669 Inhibitor L3MBTL1 L3MBTL3 repression MBT repeats inhibit transcriptional inhibitor

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