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Tradipitant

Catalog No. T17156 CAS 622370-35-8

Synonyms: VLY-686, LY686017

Tradipitant (VLY-686) is an antagonist of neurokinin-1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Tradipitant, CAS 622370-35-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
2 mg	In stock	$ 77.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 516.00
100 mg	In stock	$ 736.00
1 mL * 10 mM (in DMSO)	In stock	$ 159.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tradipitant (VLY-686) is an antagonist of neurokinin-1.
In vitro	Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus [1].
In vivo	Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands [1].

Synonyms	VLY-686, LY686017
Molecular Weight	587.9
Formula	C28H16ClF6N5O
CAS No.	622370-35-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (102.06 mM), Sonification is recommended

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library ReFRAME Related Library Clinical Compound Library

Related Products

Related compounds with same targets

Vofopitant dihydrochloride N-Acetyl-L-tryptophan Rolapitant hydrochloride Rolapitant Substance P Fosaprepitant dimeglumine Fosnetupitant chloride monohydrochloride Hemokinin 1 (human) acetate(491851-53-7 free base)

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tradipitant 622370-35-8 GPCR/G Protein Neuroscience Neurokinin receptor VLY 686 Neurokinin Receptor VLY-686 Inhibitor VLY686 LY-686017 LY 686017 NK receptor LY686017 Tachykinin receptor inhibit inhibitor

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