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Thiamine hydrochloride

Catalog No. T0894   CAS 67-03-8
Synonyms: Vitamin B1, Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride

Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

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Thiamine hydrochloride Chemical Structure
Thiamine hydrochloride, CAS 67-03-8
Pack Size Availability Price/USD Quantity
100 mg In stock $ 50.00
1 g In stock $ 68.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.05%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.
In vitro Thiamine (50 mM), in addition to its nutritional value, induces systemic acquired resistance (SAR) in rice, tobacco, cucumber, and Arabidopsis. Thiamine-treated rice, Arabidopsis (Arabidopsis thaliana), and vegetable crop plants shows resistance to fungal, bacterial, and viral infections. Thiamine treatment induces the transient expression of pathogenesis-related (PR) genes in rice and other plants. In addition, Thiamine treatment potentiates stronger and more rapid PR gene expression and the up-regulation of protein kinase C activity. [1] Vitamin B1 (10 μM) prevents acetaldehyde-induced inhibition of myocyte shortening in adult rat ventricular myocytes. Vitamin B1 (10 μM) effectively blunts the acetaldehyde-induced depression in ±dL/dt in adult rat ventricular myocytes. Vitamin B1 (10 μM) prevents acetaldehyde-induced shortening of time-to-peak shortening in adult rat ventricular myocytes. Vitamin B1 (10 μM) prevents acetaldehyde-induced elevation in both protein carbonyl formation and caspase-3 activation in adult rat ventricular myocytes. [2] Thiamine uptake is energy- and temperature-dependent, pH-sensitive, Na+-independent, saturable at both the nanomolar (apparent Km, 30 nM) and the micromolar concentration ranges in ARPE-19 cells. Uptake of Thiamine is adaptively regulated by extracellular substrate level via transcriptionally mediated mechanisms that involve both hTHTR-1 and hTHTR-2 in ARPE-19 cells, it is also regulated by an intracellular Ca2+-calmodulin-mediated pathway. [3] Thiamine-responsive megaloblastic anemia (TRMA) fibroblasts are rescued from death with 10 nM-30 nM Thiamine. Normal fibroblasts exhibits saturable, high-affinity thiamine uptake (Km 400 nM-550 nM; Vmax 11 pmol/min/1×106 cells), while TRMA fibroblasts lacks detectable high-affinity uptake. At 30 nM Thiamine, the rate of uptake of Thiamine by TRMA fibroblasts is 10-fold less than that of wild-type, which explains the increased apoptosis of TRMA fibroblasts. [4]
In vivo Thiamine deficiency results in amyloid precursor protein immunoreactivity accumulated in swollen neurites within, or around lesions in rats, or in abnormal clusters in mice. [5]
Source
Synonyms Vitamin B1, Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride
Molecular Weight 337.27
Formula C12H18Cl2N4OS
CAS No. 67-03-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (29.65 mM), sonification is recommended.

TargetMolReferences and Literature

1. Ahn IP, et al. Plant Physiol, 2005, 138(3), 1505-1515. 2. Aberle NS 2nd, et al. Alcohol Alcohol, 2004, 39(5), 450-454. 3. Subramanian VS, et al. J Physiol, 2007, 582(Pt 1), 73-85. 4. Stagg AR, et al. J Clin Invest, 1999, 103(5), 723-729. 5. Calingasan NY, et al. Neuroreport, 1997, 8(11), 2631-2634. 6. Guo Y, Suo N, Cui X, et al. Vitamin C promotes oligodendrocytes generation and remyelination[J]. Glia. 2018 Jul;66(7):1302-1316.

TargetMolCitations

1. Guo Y, Suo N, Cui X, et al. Vitamin C promotes oligodendrocytes generation and remyelination. Glia. 2018, 66(7): 1302-1316

Related compound libraries

This product is contained In the following compound libraries:
Microbial Natural Product Library Tobacco Monomer Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max Gut Microbial Metabolite Library FDA-Approved & Pharmacopeia Drug Library Traditional Chinese Medicine Monomer Library FDA-Approved Drug Library Apoptosis Compound Library

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Keywords

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