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Thalidomide-O-amido-C8-NH2

Catalog No. T17819 CAS 1950635-15-0

Synonyms: E3 Ligase Ligand-Linker Conjugates 20, Cereblon Ligand-Linker Conjugates 2

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. This compound is useful in the synthesis of PROTACs, as per reference [1].

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Thalidomide-O-amido-C8-NH2 Chemical Structure

Thalidomide-O-amido-C8-NH2, CAS 1950635-15-0

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Description	Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker. This compound is useful in the synthesis of PROTACs, as per reference [1].
In vitro	Thalidomide-O-amido-C8-NH2, referred to as Compound DL7-TL, serves as a degron-linker within the PROTAC framework, covalently connecting to both a degron and a targeting ligand. This configuration enables the degron, a molecule that binds to ubiquitin ligases (e.g., cereblon), to guide the targeting ligand toward specific proteins[1], facilitating their ubiquitination and subsequent degradation.

Synonyms	E3 Ligase Ligand-Linker Conjugates 20, Cereblon Ligand-Linker Conjugates 2
Molecular Weight	458.51
Formula	C23H30N4O6
CAS No.	1950635-15-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

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Keywords

Thalidomide-O-amido-C8-NH2 1950635-15-0 Others E3 Ligase Ligand-Linker Conjugates 20 Thalidomide O amido C8 NH2 Cereblon Ligand-Linker Conjugates 2 Thalidomide-O-amido-C-8-NH2 ThalidomideOamidoC8NH2 inhibitor inhibit

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