Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities.
Description | Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities. |
In vitro | Tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) in HT-29 cells. |
Synonyms | Deguelinol I, Hydroxydeguelin |
Molecular Weight | 410.42 |
Formula | C23H22O7 |
CAS No. | 76-80-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tephrosin 76-80-2 Others Deguelinol I Hydroxydeguelin inhibitor inhibit