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Teloxantrone HCl

Catalog No. T28944 CAS 132937-88-3

Synonyms: PD-113309, Moxantrazole, NSC-355644, CI-937, DuP-937, Teloxantrone

Teloxantrone, a DNA topoisomerase II inhibitor, is used potentially for the treatment of solid tumors.

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Teloxantrone HCl, CAS 132937-88-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Teloxantrone, a DNA topoisomerase II inhibitor, is used potentially for the treatment of solid tumors.

Synonyms	PD-113309, Moxantrazole, NSC-355644, CI-937, DuP-937, Teloxantrone
Molecular Weight	465.94
Formula	C21H28ClN5O5
CAS No.	132937-88-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Armand JP. New anticancer drugs in Europe. Gan To Kagaku Ryoho. 1997 May;24 Suppl 1:70-93. Review. PubMed PMID: 9210890. 2. Gogas H, Mansi JL. New drugs. The anthrapyrazoles. Cancer Treat Rev. 1996 Nov;21(6):541-52. Review. PubMed PMID: 8599804. 3. Renner U, Blanz J, Freund S, Waidelich D, Ehninger G, Zeller KP. Biotransformation of CI-937 in primary cultures of rat hepatocytes. Formation of glutathione conjugates. Drug Metab Dispos. 1995 Jan;23(1):94-101. PubMed PMID: 7720531. 4. Raghavan K, Nemeth G, Gray D, Hussain MA. Stabilization of an anthrapyrazole antitumour agent, DuP 937, on complexation with heptakis(2,6-di-O-methyl)-beta-cyclodextrin in aqueous solution. J Pharm Biomed Anal. 1994 Oct;12(10):1259-64. PubMed PMID: 7841220.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Teloxantrone HCl 132937-88-3 CI937 PD-113309 Moxantrazole NSC-355644 CI-937 CI 937 DuP-937 DuP 937 DuP937 NSC 355644 PD 113309 Teloxantrone PD113309 NSC355644 inhibitor inhibit

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