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Tecastemizole

Catalog No. T26253 CAS 75970-99-9

Synonyms: Norastemizole, R-43512, R43512, R 43512, T 1348

Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects.

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Tecastemizole, CAS 75970-99-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 87.00
5 mg	In stock	$ 213.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 533.00
50 mg	In stock	$ 768.00
100 mg	In stock	$ 1,080.00
500 mg	In stock	$ 2,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 235.00

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Purity: 99.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects.

Synonyms	Norastemizole, R-43512, R43512, R 43512, T 1348
Molecular Weight	324.4
Formula	C19H21FN4
CAS No.	75970-99-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (292.85 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17. 2. Schneider E, et al. Magnetic resonance spectroscopy for measuring the biodistribution and in situ in vivo pharmacokinetics of fluorinated compounds: validation using an investigation of liver and heart disposition of tecastemizole. J Clin Pharm Ther. 2006 Jun;31(3):261-73. 3. Vlaar T, et al. Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion. Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13058-61. 4. Paakkari I. Cardiotoxicity of new antihistamines and cisapride. Toxicol Lett. 2002 Feb 28;127(1-3):279-84. Review.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Human Metabolite Library Neuronal Signaling Compound Library ReFRAME Related Library Neurotransmitter Receptor Compound Library Bioactive Compound Library

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Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tecastemizole 75970-99-9 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor T-1348 anti-inflammatory Inhibitor Norastemizole T1348 allergy R-43512 inhibit R43512 R 43512 T 1348 inhibitor

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